WNT10B, one member of the Wnt family, was first found in human breast carcinoma, and several studies have been performed to identify the relationship between WNT10B and human diseases. Wingless-type MMTV integration sites (WNTs) are secreted glycoproteins that function as signaling molecules and are involved in numerous events in human organogenesis, physiology, and pathology. However, few genetic polymorphisms have been associated with the Yin Deficiency pattern. Around the same time, our research group also reported that the C-399T variation of the neuropeptide Y (NPY) gene was associated with the Dampness-Phlegm pattern in Korean stroke patients. Recently, we reported that L55 M and C-2033T alleles of the Paraoxonase 1 (PON1) gene, which were correlated with stroke in an East Asian population, were associated with the Dampness-Phlegm pattern among Korean stroke patients. For example, a study in Chinese patients with coronary heart disease reported that the frequencies of the allele and genotype of the apolipoprotein E gene were significantly higher in patients with the phlegm pattern than in patients with the blood stasis pattern. However, some reports have shown that inherent factors, such as genetic variations, are correlated with PI. PI is affected by various environmental factors, such as climate, diet, and lifestyle. Conversely, patients with the Qi Deficiency or Dampness-Phlegm patterns tend to be overweight or obese. Furthermore, the Yin Deficiency pattern is typically associated with thinness. The Yin Deficiency pattern indicates a pattern/syndrome resulting from a deficiency of yin fluid and essence, incapable of restraining yang. Previous reports have described the PI process for differentiating stroke victims with four TKM types: the Fire-Heat pattern, Dampness-Phlegm pattern, Yin Deficiency pattern, and Qi Deficiency pattern. Traditional Korean medicine (TKM), similar to traditional Chinese medicine (TCM), categorizes these phenotypes as patterns, and the procedure for determining the pattern of a particular patient is called “pattern identification” (PI). Patients with a specific disease exhibit various phenotypes, signs, and symptoms reflecting the cause, nature, and location of the illness, the patient’s physical condition, and the patient’s treatment. These results suggest that G-607C might be used as a diagnostic genetic marker for Yin Deficiency pattern in stroke patients and in the development of personalized medical care. This is the first study to demonstrate an association between a WNT10B polymorphism and the Yin Deficiency pattern of traditional Korean medicine (TKM) in a CI patient population. The frequency of the CC genotype of G-607C in the Yin Deficiency pattern group (29.33%) was significantly higher than that in the Non-Yin Deficiency pattern group (23.96%) ( The results were analyzed using a multiple logistic regression model to evaluate the genetic association between the G-607C variant and Yin Deficiency pattern. SNP (G-607C) genotyping was conducted by primer extension using TaqMan probe five percent of subjects were regenotyped by direct sequencing to confirm the accuracy of the genotyping. A total of 630 CI patients, including 75 with Yin Deficiency pattern and 555 with Non-Yin Deficiency pattern, participated in this study. In this study, we analyzed the distribution of WNT10B polymorphism in elderly Korean subjects with cerebral infarction (CI) and Yin Deficiency pattern and Non-Yin Deficiency pattern. WNT10B has been indicated as a potential regulator of adipogenesis in vivo and in vitro models of obesity.
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